Depression drug may relieve pain from breast cancer treatment
"Since women typically take these drugs by reason of five years, it is important that the margin effects not interfere too much with their quality of life, or they wish be less likely to continue alluring the medicine, which may lead to a greater hazard of their breast cancer returning," says study original N. Lynn Henry, M.D., Ph.D., assistant professor of incorporeal medicine at the U-M Medical School.
Henry leave present the initial results of the study Dec. 11 at the 33rd Annual San Antonio Breast Cancer Symposium.
The study looked at the medicine duloxetine, or Cymbalta, which is used to use depression and generalized anxiety disorder. It’s also been shown to work in multiple other of long duration pain conditions, such as fibromyalgia and, besides recently, osteoarthritis. It is believed to reduction pain through its actions in the central powerful system.
Of 29 patients evaluated, penuriously three-quarters reported that their throe had decreased by at least 30 percent. On average, after eight weeks of treatment, care scores declined 61 percent. Only single in kind in five patients stopped taking duloxetine for the reason that of side effects.
"Duloxetine appears to exist effective at reducing the muscle and seam pain many women experience from aromatase inhibitors, by only mild additional side effects," Henry says.
The researchers are planning a randomized, controlled test of virtue comparing duloxetine to placebo. Henry is in addition doing research looking at the tenor of aromatase inhibitors on pain cognition to better understand why women open pain.
Breast cancer statistics: 209,060 Americans wish be diagnosed with breast cancer this year and 40,230 direction die from the disease, according to the American Cancer Society
Additional U-M authors: Mousumi Banerjee, Ph.D., Dorothy Blossom, Max Wicha, M.D., Catherine Van Poznak, M.D., Jeffrey Smerage, M.D., Ph.D., Anne Schott, M.D., Jennifer Griggs, M.D., M.P.H., and Daniel Hayes, M.D.
Funding: Supported through . an Investigator Initiated Grant from Lilly Pharmaceuticals
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